NL West Featured - Sasaki Returns
MLB.TV / SportsNet LA

Giants @ Dodgers

Monday, 10:10 PM ET | Dodger Stadium, Los Angeles, CA

Roki Sasaki returns to the mound at Dodger Stadium Monday night for the rival series opener against the San Francisco Giants in the marquee pitching spot of the entire Monday slate. Sasaki is 1-3 with a 5.97 ERA through his first eight starts of the 2026 season and is working on eight days of rest after the Dodgers skipped his last turn with Blake Snell returning from a rehab assignment. The matchup is the Japanese right-hander's first career start against the Giants and the kind of NL West rivalry environment that books typically weight for early-season variance, with Los Angeles entering the night at 24-15 and leading the division and San Francisco at 15-24 sitting fifth in the West.

Trevor McDonald takes the ball for the Giants in his second start since the latest recall to the major-league rotation. McDonald threw seven innings of one-run, two-hit ball with eight strikeouts and no walks in his season debut, the kind of right-hander breakout line that prompted the Giants to move him directly into the rotation rather than keep him on a piggy-back schedule. McDonald is 1-0 with a 1.29 ERA, the strikeout per inning profile playing up against a left-leaning Dodgers lineup that ranks among the top NL offensive units in expected wOBA against right-handed starters. The pitching matchup is the lever that books are pricing into a tight market with the over/under and moneyline reflecting both rotation arms being live for the four-game series opener.

The Dodgers have leaned on the home-field profile that produced the World Series run in 2025 across the entire spring of 2026, and the Sasaki workload is the variable Dave Roberts has rotated through the rest-and-skip approach Andrew Friedman's office has used to keep the Japanese right-hander healthy for the second half. The Giants enter the night on a 4-loss-of-last-5 stretch with the road profile that has not held up in the early innings of late, and the matchup against Sasaki is the kind of spot where the visitors need the McDonald scoring suppression to hold through the middle innings. First pitch is 10:10 PM ET on SportsNet LA and NBC Sports Bay Area regionally with MLB.TV national.

AL East
MLB.TV / Sportsnet

Rays @ Blue Jays

Monday, 7:07 PM ET | Rogers Centre, Toronto, ON

The Tampa Bay Rays send Drew Rasmussen to the Rogers Centre mound against Kevin Gausman in one of the strongest top-of-the-rotation pitching matchups across the entire Monday card. Rasmussen carries a 2-1 record with a 2.64 ERA and 0.85 WHIP through his first nine starts of the season, the kind of efficiency profile that has carried the Rays' rotation across the early run. The Rasmussen splitter against the Blue Jays' right-handed-heavy lineup is the strikeout matchup to track in the middle innings, with the strikeout prop set at 4.5 and the over/under priced near pick-em.

Kevin Gausman responds for Toronto at 2-2 with a 3.10 ERA and 0.96 WHIP, the splitter-and-four-seam combination that has remained the Blue Jays' top-of-rotation anchor across multiple seasons. Gausman's strikeout pace has held at career-typical levels into mid-May, and the matchup against the Rays' lefty-leaning order will lean on his ability to manage the heart of the Tampa Bay lineup through six innings. Tampa Bay opens the three-game set as a slight moneyline favorite at around -130 with the over/under reflecting both rotation arms in play through the middle innings. First pitch is 7:07 PM ET on Sportsnet regionally with MLB.TV national.

AL West
FS1

Mariners @ Astros

Monday, 8:10 PM ET | Daikin Park, Houston, TX

George Kirby returns to Daikin Park with the kind of career history against the Astros that books always weight when pricing AL West matchups. Kirby is 4-2 with a 2.94 ERA through his first 2026 starts and carries a career mark of 4-1 with a 2.17 ERA in 10 starts against Houston. The combination of the elite walk rate, the swing-and-miss four-seam at the top of the zone, and the matchup history against the Astros' core has driven Seattle to a -144 road moneyline favorite with the run-line at -1.5 and the strikeout prop set at 5.5 for Kirby's start.

Peter Lambert takes the ball for Houston at 2-2 with a 2.42 ERA through eight starts, the kind of ERA profile that has held the Astros' rotation together while the team navigated the early-season offensive struggles. Houston enters Monday at 16-24 and fourth in the AL West, with Seattle at 19-21 and second. The early-season head-to-head has swung Seattle's way with a four-game sweep already on the books, and the Kirby-against-Lambert pitching matchup is the early-game lever that books built the moneyline gap around. First pitch is 8:10 PM ET on FS1.

AL East
YES / MASN

Yankees @ Orioles

Monday, 6:35 PM ET | Oriole Park at Camden Yards, Baltimore, MD

Ryan Weathers makes his first start since May 2 after being skipped with an illness, taking the ball at Camden Yards as the Yankees open the road series. Weathers is 2-2 with a 3.03 ERA through his first seven starts of the season, the kind of left-handed efficiency profile that has anchored the back end of the Yankees' rotation while the team navigated the Brewers sweep that left them on a four-of-five losing run heading into this trip. New York opens as a heavy -172 moneyline favorite, an implied probability of 63.2 percent, with Baltimore at +144 on the home side.

Brandon Young responds for the Orioles at 3-1 with a 4.35 ERA through his first seven starts, the kind of right-handed contact profile that has produced two wins of the last five for the Baltimore rotation. The Yankees enter at 26-15, the Orioles at 18-23 and seventh in the AL East, with the home-side variance built into the +144 underdog price. The combination of the Weathers return from illness, the New York losing run from the Milwaukee series, and the Baltimore home-side fight for early-season ground sets the table for the kind of AL East spot that books price with the moneyline gap and a tight 8.5 to 9 total. First pitch is 6:35 PM ET on YES and MASN.

AL West
Bally Sports

Diamondbacks @ Rangers

Monday, 8:05 PM ET | Globe Life Field, Arlington, TX

Michael Soroka takes the ball for the Arizona Diamondbacks at Globe Life Field against Nathan Eovaldi and the Texas Rangers in the second meeting of the season between the two clubs. Soroka is 4-2 with a 4.14 ERA across 37 innings of work, the right-handed sinker-and-slider profile that has carried the Arizona rotation depth across the spring. The matchup against the Rangers' right-leaning order will lean on Soroka's ability to land the sinker for early-count contact and avoid the high-leverage at-bats in the middle innings.

Nathan Eovaldi answers for Texas at 4-4 with a 4.15 ERA across 47.2 innings. Eovaldi's recent run has shown the kind of bounce-back profile that World Series-winning veterans build their seasons around, and the matchup against an Arizona offensive group that has held together despite roster turnover is the spot Texas needs to lock down at home as the Rangers reset the AL West chase. The line opens at Texas -122, Arizona +102 with the total at 8.5, the kind of moderate run-environment over-under that books typically set when both starters are right-handed veterans with mid-4 ERAs. First pitch is 8:05 PM ET on Bally Sports.

AL Central
Bally Sports

Angels @ Guardians

Monday, 6:10 PM ET | Progressive Field, Cleveland, OH

Joey Cantillo takes the ball for the Cleveland Guardians at Progressive Field against the Los Angeles Angels in the series opener of the three-game set. Cantillo is 2-1 with a 3.43 ERA across 39.1 innings of action, the kind of left-handed profile that has produced the Cleveland rotation depth around the top of the staff. Cleveland opens as a moneyline favorite around -128 with the Angels at +106 on the road and the total set in the 7.5-to-9 range across major books.

The Angels' rotation slot is listed as undecided as of the Sunday-night card, which adds the kind of pitching uncertainty books typically build into the over/under and the run-line price. Cleveland enters with the steady run-environment profile at Progressive Field, the Guardians' bullpen has remained one of the highest-leverage units in the AL Central, and the matchup against an Angels lineup that has struggled to produce sustained scoring against left-handed starters is the lever Cleveland will pull against the visiting rotation. First pitch is 6:10 PM ET on Bally Sports.